University of Turin
Department of Medical Sciences and Laboratory of Experimental Pathology at Candiolo Cancer Institute (UNITO)
The Department of Medical Sciences at the University of Turin includes several specialties including Oncology and Research Laboratories are located at different Institutions. The research described in the project will be carried out at the Experimental Molecular Pathology laboratory of FPO-IRCCS Candiolo Cancer Institute, a Comprehensive Cancer Centre that is member of the OECI (Organization of European Cancer Institutes). The Experimental Molecular Pathology laboratory is connected with the Diagnostic Pathology Unit, which is under the supervision of Prof. Marchiò and includes all the facilities for histopathology, automated immunohistochemistry, micro dissection with stereomicroscopes, slide scanning, cytogenetic analysis, NanoString technology, thus ensuring the complete workflow of analyses included in the present project.
Role
The Experimental Molecular Pathology laboratory will play a crucial role in the project since it will represent one of the two Central Labs for Prosigna testing on tissue specimens, which is needed to characterise and randomise patients within the trial.
Members
Caterina Marchiò
Prof. Caterina Marchiò is Associate Professor of Pathology at the University of Turin and she is an experimental pathologist leading the Experimental Molecular Pathology Laboratory at the FPO-IRCCS Candiolo Cancer Institute. Prof. Marchiò serves as referral breast pathologist at the Pathology Unit of Candiolo Cancer Institute, where she is also responsible for Molecular Diagnostics.
Prof. Marchiò is devoted to deconvolute the complexity of pathology to foster precision medicine. The main focus of her laboratory is the molecular profiling of tumoral lesions across tissue samples, with a specific interest in breast cancer (including tumors, pre-invasive lesions and normal counterparts), with the final aim to design and select effective therapies and curtail treatment resistance. The lab is also actively involved in the standardisation of preanalytical conditions of tissue sample management and processing to guarantee quality of DNA, RNA and antigens.
Enrico Berrino
Dr. Berrino is a molecular Biologist with strong experience on high throughput molecular analyses n FFPE tissue specimens, in particular in the breast cancer field.
Sara Erika Bellomo
Dr. Bellomo is a Bioinformatician with solid experience on transcriptomic analysis of breast carcinomas.
Anita Chesta
Dr. Chesta is a biologist with strong background in FFPE tissue handling and management with a particular focus on breast cancer specimens.