{"id":613,"date":"2025-05-27T19:06:57","date_gmt":"2025-05-27T17:06:57","guid":{"rendered":"https:\/\/path-for-young.unicancer.fr\/?page_id=613"},"modified":"2026-03-12T09:01:05","modified_gmt":"2026-03-12T08:01:05","slug":"project-organization-workpackages","status":"publish","type":"page","link":"https:\/\/path-for-young.unicancer.fr\/es\/path-for-young\/project-organization-workpackages\/","title":{"rendered":"Project organization &amp; workpackages"},"content":{"rendered":"\n<div class=\"wp-block-uagb-container uagb-block-2e71aa97 alignfull uagb-is-root-container\"><div class=\"uagb-container-inner-blocks-wrap\"><div class=\"plmb plmb-text mce-content clearfix format-intro\">\r\n\t<h1>Project organization<br \/>\n&amp; workpackage<\/h1>\n<p><span aria-hidden=\"true\"><\/span><\/p>\n<\/div>\r\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-uagb-container uagb-block-6c22ed55 alignfull uagb-is-root-container\"><div class=\"uagb-container-inner-blocks-wrap\"><div class=\"plmb plmb-image image-style-none\">\r\n\t\t<figure style=\"width:100%\">\r\n\t\t<div class=\"image-wrapper\" style=\"height:580px\"><img loading=\"lazy\" decoding=\"async\" width=\"1920\" height=\"957\" src=\"https:\/\/path-for-young.unicancer.fr\/wp-content\/uploads\/2025\/07\/wp-2-1920x957.png\" class=\"attachment-fhd size-fhd\" alt=\"\" srcset=\"https:\/\/path-for-young.unicancer.fr\/wp-content\/uploads\/2025\/07\/wp-2-1920x957.png 1920w, https:\/\/path-for-young.unicancer.fr\/wp-content\/uploads\/2025\/07\/wp-2-300x149.png 300w, https:\/\/path-for-young.unicancer.fr\/wp-content\/uploads\/2025\/07\/wp-2-1024x510.png 1024w, https:\/\/path-for-young.unicancer.fr\/wp-content\/uploads\/2025\/07\/wp-2-768x383.png 768w, https:\/\/path-for-young.unicancer.fr\/wp-content\/uploads\/2025\/07\/wp-2-1536x765.png 1536w, https:\/\/path-for-young.unicancer.fr\/wp-content\/uploads\/2025\/07\/wp-2-2048x1020.png 2048w, https:\/\/path-for-young.unicancer.fr\/wp-content\/uploads\/2025\/07\/wp-2-300x149@2x.png 600w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/><\/div>\t<\/figure>\r\n\t\t<\/div>\r\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-uagb-container uagb-block-1bb655a8 alignfull uagb-is-root-container\"><div class=\"uagb-container-inner-blocks-wrap\">\n<div class=\"wp-block-uagb-container uagb-block-b6fd5ff1\"><div class=\"plmb plmb-text mce-content clearfix format-classic\">\r\n\t<h2><span style=\"font-size: 20px\">WP1-3 Optima-Young RCT Organization<\/span><\/h2>\n<p>WP1-3 Optima-young Organization: Two twin trials are associated with Path-for-Young: Optima-young sponsored by UNICANCER conducted on pre-menopausal patients and OPTIMA sponsored by University College of London (UCL) operated by University of Warwick conducted on pre-menopausal and post-menopausal women. Both Optima-young and <a href=\"https:\/\/www.optimabreaststudy.com\/index.php\">OPTIMA<\/a> are international, randomized, two arm clinical studies to verify wheter the use of a genomic test (Prosigna<sup>\u00ae<\/sup>) to decide whether or not to administer chemotherapy gives results as good as standard treatment (systematic chemotherapy) in premenopausal women with hormone-dependent (HR+)\/HER2- breast cancer, by assessing their risk of cancer recurrence.<\/p>\n<ul>\n<li>Multiparameter gene expression assay: Several tests have been developed to study the genes present in breast cancer cells. These tests measure the degree of activity of some of these genes. They are used to guide and improve the choice of treatments by providing precise information about each cancer. These tests are sometimes called multiparametric tests.<\/li>\n<li>Digital platform WeShare: The Path-for-young project deploys a dedicated digital infrastructure and data collection web platform (WeShare), leveraging decentralized collection of longitudinal patient-generated-data to evaluate patient quality of life and key toxicities.<br \/>\n<a class=\"cta mini-green\" href=\"https:\/\/weshare.unicancer.com\" target=\"_blank\" rel=\"noopener\">Access to WeShare Website<\/a><\/li>\n<li>Digital Health Tools: A substudy of Optima-young RCT, which will formally test, among participating patients from 3 European countries a digital<br \/>\ncompanion to deliver enhanced follow-up care providing care patients with a personalized supportive care pathway to manage side effects associated with endocrine therapy to maximize quality of life, self-efficacy and empowerment, and clinical outcomes via improved treatment adherence<a href=\"https:\/\/www.resilience.care\/en\" target=\"_blank\" rel=\"noopener\"> link to Resilience.<\/a><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<\/div>\r\n\n\n<div class=\"plmb plmb-text mce-content clearfix format-classic\">\r\n\t<h2><span style=\"font-size: 20px\">WP 4 Patient engagement and co-creation<\/span><\/h2>\n<p>The project practices co-creation with multiple stakeholders, primarily patients and HCP with relevant experience, throughout the entire duration of the project beginning during protocol development, to enhance trial recruitment and implementation as well as ensuring that key patient needs are integrated into integratedto the trial development and conduct. <a href=\"https:\/\/path-for-young.unicancer.fr\/es\/patient-engagement-and-representation\/\" target=\"_blank\" rel=\"noopener\">link to section patient engagement.<\/a><\/p>\n<\/div>\r\n\n\n<div class=\"plmb plmb-text mce-content clearfix format-classic\">\r\n\t<h2><span style=\"font-size: 20px\">WP5-7 Statistical anaylsis<\/span><\/h2>\n<p>This work package will analyze the data collected during the Optima-young study&nbsp;:<br \/>\nAll the tasks related to planning of the statistical analyses of the Optima-young RCT, as well as the first interim analysis to study robustness of the initial study hypotheses will be done within the work package 5. The main statistical analysis and reporting of the clinical trial, and the analyses of secondary endpoints using the last data lock at the end of the clinical trial among all enrolled patients will be done within the work package 7.<\/p>\n<\/div>\r\n<\/div>\n\n\n\n<div class=\"wp-block-uagb-container uagb-block-ad7e6422\"><div class=\"plmb plmb-text mce-content clearfix format-classic\">\r\n\t<h2><span style=\"font-size: 20px\">WP 6 The work package 6 <\/span><\/h2>\n<p>The work package 6 will ensure that the first analyses of the digital companion substudy, which will test the effectiveness of existing personalized digital health tools to address issues of particular relevance to premenopausal patients in a personalized supportive care pathway. In addition, the WP will have the objective to evaluate issues of relevance to premenopausal patients, and of the societal impact of the Optima-young RCT personalized approach.<\/p>\n<\/div>\r\n\n\n<div class=\"plmb plmb-text mce-content clearfix format-classic\">\r\n\t<h2><span style=\"font-size: 20px\">WP 8-9 HTA<\/span><\/h2>\n<p>The aim is to assess the efficiency and budgetary impact of the use of the genomic test to guide the prescription of the chemotherapy and to prepare the health system to the adoption of the new strategy.<\/p>\n<ul>\n<li>the work package 8 will describe the current use of technology and technical characteristics across the international HTA partners; plan a cross-country cost and economic effectiveness to develop a methodology ensuring transferability to all EU countries and will perform an ethical analysis, and do analysis including organisational, patient, social, and legal aspects;<\/li>\n<li>the work package 9 will deliver the Health Technology Assessment including the health economic analyses and to ensure that the Optima-young RCT findings are implemented in the real-world;<\/li>\n<\/ul>\n<\/div>\r\n\n\n<div class=\"plmb plmb-text mce-content clearfix format-classic\">\r\n\t<h2><span style=\"font-size: 20px\">WP 10- 11 Communication<\/span><\/h2>\n<p>A dedicated work package will work on the communication of the project to raise awareness of the project among the general public and the scientific community through publications on social networks and in medical networks.<\/p>\n<\/div>\r\n\n\n<div class=\"plmb plmb-text mce-content clearfix format-classic\">\r\n\t<h2><span style=\"font-size: 20px\">WP12-14 Management of the project<\/span><\/h2>\n<p>The aim of this work package is to coordinate all the parties involved in the project to ensure quality and the achievement of objectives within the allotted timeframe<\/p>\n<\/div>\r\n<\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-uagb-container uagb-block-3703e03e alignwide uagb-is-root-container\">\n<div class=\"wp-block-uagb-container page-nav-blue uagb-block-b277c911\"><div class=\"plmb plmb-image image-style-none\">\r\n\t\t<figure style=\"width:80px\">\r\n\t\t<div class=\"image-wrapper\" style=\"height:80px\"><img loading=\"lazy\" decoding=\"async\" width=\"1\" height=\"1\" src=\"https:\/\/path-for-young.unicancer.fr\/wp-content\/uploads\/2025\/05\/left-arrow.svg\" class=\"attachment-fhd size-fhd\" alt=\"previous page\" \/><\/div>\t<\/figure>\r\n\t\t<\/div>\r\n\n\n<div class=\"plmb plmb-text mce-content clearfix format-light-margin-title\">\r\n\t<h3 style=\"text-align: left\"><span style=\"font-size: 25px\">Objectives of the Path-for-Young project<\/span><\/h3>\n<\/div>\r\n<a class=\"spectra-container-link-overlay\" rel=\"noopener\" href=\"https:\/\/path-for-young.unicancer.fr\/path-for-young\/objectives-of-the-path-for-young-project\/\"> <\/a><\/div>\n\n\n\n<div class=\"wp-block-uagb-container page-nav-green uagb-block-00ee5efe\"><div class=\"plmb plmb-image image-style-none\">\r\n\t\t<figure style=\"width:80px\">\r\n\t\t<div class=\"image-wrapper\" style=\"height:80px\"><img loading=\"lazy\" decoding=\"async\" width=\"1\" height=\"1\" src=\"https:\/\/path-for-young.unicancer.fr\/wp-content\/uploads\/2025\/05\/right-arrow.svg\" class=\"attachment-fhd size-fhd\" alt=\"next page\" \/><\/div>\t<\/figure>\r\n\t\t<\/div>\r\n\n\n<div class=\"plmb plmb-text mce-content clearfix format-light-margin-title\">\r\n\t<h3 style=\"text-align: right\"><span style=\"font-size: 25px\">Ambition of the<\/span><br \/>\n<span style=\"font-size: 25px\">Path-for-young Project<\/span><\/h3>\n<\/div>\r\n<a class=\"spectra-container-link-overlay\" rel=\"noopener\" href=\"https:\/\/path-for-young.unicancer.fr\/path-for-young\/ambition-of-the-path-for-young-project\/\"> <\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":526,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","_analytify_skip_tracking":false,"footnotes":""},"class_list":["post-613","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Project organization &amp; 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